BDBM50304862 4-(3-fluorophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H-pyrazol-3(2H)-one::CHEMBL593000

SMILES Cn1c(c(-c2cccc(F)c2)c(=O)n1C)-c1ccc2nccnc2c1

InChI Key InChIKey=FOPPVQWVXVOECD-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50304862   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50304862(4-(3-fluorophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50304862(4-(3-fluorophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl...)
Affinity DataIC50:  990nMAssay Description:Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed