BDBM50305735 CHEMBL595990::N,N'-(1,2-phenylene)bis(N-methyl-1-phenylmethanesulfonamide)

SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=WOBGBOUAUABUFZ-UHFFFAOYSA-N

Data  7 IC50  1 EC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50305735   

TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataIC50: 200nMAssay Description:Displacement of [125I]human anaphylatoxin C5a from human C5a receptor expressed in CHO cells co-expressed with Galpha16 after 1 hrMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as inhibition of anaphylatoxin C5a-induced intra...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of CXCR4 in human T cellsMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human P2Y2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataIC50: 6.00E+4nMAssay Description:Antagonist activity at C5a receptor in rat RAW264.7 cells assessed as inhibition of anaphylatoxin C5a-induced intracellular calcium accumulation afte...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of CXCR3 in human T cellsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305735(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
Affinity DataIC50: 6.70nMAssay Description:Antagonist activity at C5a receptor in human PMNC assessed as inhibition of anaphylatoxin C5a-induced intracellular calcium accumulation after 10 min...More data for this Ligand-Target Pair