BDBM50305818 1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione::CHEMBL593506::cid_45281794

SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1

InChI Key InChIKey=SPBGRXOPAXZSER-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50305818   

TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels And Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50305818(1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoli...)
Affinity DataEC50: >442nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGroup 3 secretory phospholipase A2(Homo sapiens)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50305818(1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoli...)
Affinity DataIC50:  3.20E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels And Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50305818(1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoli...)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels And Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50305818(1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoli...)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50305818(1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoli...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed