BDBM50306124 6-(5-chlorospiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-(pyridin-3-yl)ethyl)pyridazine-3-carboxamide::CHEMBL595254

SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1c(Cl)cccc1O2)c1cccnc1

InChI Key InChIKey=LNGYRMQFDYVKMZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306124   

TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306124(6-(5-chlorospiro[chroman-2,4'-piperidine]-1'-yl)-N...)
Affinity DataIC50:  1nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306124(6-(5-chlorospiro[chroman-2,4'-piperidine]-1'-yl)-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human SCD1 expressed in human 293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306124(6-(5-chlorospiro[chroman-2,4'-piperidine]-1'-yl)-N...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed