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BDBM50308889 4-Methoxy-N-[3-(2-pyridin-4-yl-ethylcarbamoyl)-benzyl]-benzamide::CHEMBL596708

SMILES: COc1ccc(cc1)C(=O)NCc1cccc(c1)C(=O)NCCc1ccncc1

InChI Key: InChIKey=WWPWTEOCRKWNBN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308889   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50308889
PNG
(4-Methoxy-N-[3-(2-pyridin-4-yl-ethylcarbamoyl)-ben...)
Show SMILES COc1ccc(cc1)C(=O)NCc1cccc(c1)C(=O)NCCc1ccncc1
Show InChI InChI=1S/C23H23N3O3/c1-29-21-7-5-19(6-8-21)22(27)26-16-18-3-2-4-20(15-18)23(28)25-14-11-17-9-12-24-13-10-17/h2-10,12-13,15H,11,14,16H2,1H3,(H,25,28)(H,26,27)
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Similars

Article
PubMed
n/an/a>7.00E+6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human ROCK2 by IMAP assay


J Med Chem 53: 759-77 (2010)


Article DOI: 10.1021/jm9014263
BindingDB Entry DOI: 10.7270/Q2V125RD
More data for this
Ligand-Target Pair