BDBM50313818 5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-methylimidazolidine-2,4-dione::CHEMBL1078396

SMILES COc1ccc2[nH]n(CC3(C)NC(=O)NC3=O)c(=O)c2c1

InChI Key InChIKey=PIEMRKVLYXWKFP-UHFFFAOYSA-N

Data  8 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50313818   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  23nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of ADAM9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.29E+4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  3.19E+4nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313818(5-((5-methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed