BDBM50316252 CHEMBL1095626::methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(N)cc1)N1CCOCC1

InChI Key InChIKey=OFIHBQUKIUHAHV-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50316252   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IKKalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50:  801nMAssay Description:Inhibition of PI3Kalpha by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50:  6.22E+3nMAssay Description:Inhibition of PI3Kgamma by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ATR by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of LYN AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50:  2.89E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform gamma-1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of CK1gamma1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of RSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316252(CHEMBL1095626 | methyl 4-(6-(4-aminophenyl)-4-morp...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed