BDBM50318300 CHEMBL1095097::EPLERENONE::SC-66110
SMILES COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]23O[C@@H]2C[C@@]2(C)[C@@H](CC[C@@]22CCC(=O)O2)[C@H]13
InChI Key InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 50318300
Affinity DataKi: 44nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 126nMAssay Description:Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.16E+3nMAssay Description:Binding affinity to recombinant human GR LBD by fluormone GS red-fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Binding affinity to recombinant human progesterone receptor LBD by fluormone PL red-fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Antagonist activity at human mineralocorticoid receptor assessed as inhibition of binding to coactivator peptide by NH Pro assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonist activity at progesterone receptor beta (unknown origin) by NH Pro assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at progesterone receptor beta (unknown origin) by NH Pro assayMore data for this Ligand-Target Pair
Affinity DataIC50: 244nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 122nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-Dexamethasone from glucocorticoid receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in COS1 cells after 1 day by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [3H]aldosterone from human mineralocorticoid receptor expressed in 293 cells after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]testosterone from androgen receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [[3H]-Progesterone from progesterone receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]progestrone from PRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human MR transfected in human COS1 cells after 1 day by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]dexomethasone from GRMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]testosterone from ARMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [3H]aldosterone from cytosolic human MR expressed in HEK293 cells after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 122nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 122nMAssay Description:Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at androgen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >8.94E+3nMAssay Description:Antagonist activity at glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at progesterone receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at estrogen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 794nMAssay Description:Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid re...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Antagonist activity at full length human mineralocorticoid receptor expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 244nMAssay Description:Antagonist activity at human full-length MCR assessed as inhibition of receptor binding to co-activator peptide by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [3H]-estradiol from recombinant full-length human estrogen beta receptor expressed in baculovirus infected insect cells incubated ove...More data for this Ligand-Target Pair
Affinity DataIC50: 226nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Displacement of [3H]-methyltrienolene from human androgen receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.38E+4nMAssay Description:Displacement of [3H]-dexamethasone from recombinant full length human glucocorticoid receptor expressed in baculovirus infected insect cells incubate...More data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at glucocorticoid receptor (unknown origin) by NH Pro assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at glucocorticoid receptor (unknown origin) by NH Pro assayMore data for this Ligand-Target Pair
Affinity DataIC50: 178nMAssay Description:Antagonist activity at human wild-type mineralocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of aldosterone-induced transcripti...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonist activity at androgen receptor (unknown origin) by NH Pro assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at androgen receptor (unknown origin) by NH Pro assayMore data for this Ligand-Target Pair