BDBM50318652 (E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3-chlorophenyl)-4-oxobutanamide::4-[2-(anthracen-9-ylmethylidene)hydrazino]-N-(3-chlorophenyl)-4-oxobutanamide::CHEMBL1084866::NadD inhibitor 1_02::US8785499, 1_02

SMILES Clc1cccc(NC(=O)CCC(=O)N\N=C\c2c3ccccc3cc3ccccc23)c1

InChI Key InChIKey=OJLFRDWWYAPUAJ-JVWAILMASA-N

Data  6 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50318652   

TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  5.00E+3nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  8.00E+3nM IC50:  1.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  9.00E+3nM IC50:  2.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of NaMN substrate by malachite gre...More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  1.00E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of ATP substrate by malachite gree...More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of substrate by malachite green re...More data for this Ligand-Target Pair
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataIC50:  1.50E+4nMpH: 7.5 T: 2°CAssay Description:A general phosphate detection assay method using Malachite Green reagent was adapted to measure the activity of NaMN adenylyltransferaseA14. Briefly,...More data for this Ligand-Target Pair
In DepthDetails US Patent