BDBM50319002 2-(2-(4-(2-hydroxy-3-(2-isopropylphenoxy)propyl)piperazin-1-yl)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione::CHEMBL1083053

SMILES CC(C)c1ccccc1OCC(O)CN1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1

InChI Key InChIKey=ANJWGYQQGXYHGI-UHFFFAOYSA-N

Data  3 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50319002   

TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
4SC AG

Curated by ChEMBL
LigandPNGBDBM50319002(2-(2-(4-(2-hydroxy-3-(2-isopropylphenoxy)propyl)pi...)
Show SMILES CC(C)c1ccccc1OCC(O)CN1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1
Show InChI InChI=1S/C30H35N3O4/c1-21(2)24-9-3-4-12-27(24)37-20-23(34)19-32-15-13-31(14-16-32)17-18-33-29(35)25-10-5-7-22-8-6-11-26(28(22)25)30(33)36/h3-12,21,23,34H,13-20H2,1-2H3
Affinity DataKi:  70nMAssay Description:Displacement of [125I]cyanopindolol from human adrenergic beta2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
4SC AG

Curated by ChEMBL
LigandPNGBDBM50319002(2-(2-(4-(2-hydroxy-3-(2-isopropylphenoxy)propyl)pi...)
Show SMILES CC(C)c1ccccc1OCC(O)CN1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1
Show InChI InChI=1S/C30H35N3O4/c1-21(2)24-9-3-4-12-27(24)37-20-23(34)19-32-15-13-31(14-16-32)17-18-33-29(35)25-10-5-7-22-8-6-11-26(28(22)25)30(33)36/h3-12,21,23,34H,13-20H2,1-2H3
Affinity DataKi:  740nMAssay Description:Antagonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
4SC AG

Curated by ChEMBL
LigandPNGBDBM50319002(2-(2-(4-(2-hydroxy-3-(2-isopropylphenoxy)propyl)pi...)
Show SMILES CC(C)c1ccccc1OCC(O)CN1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1
Show InChI InChI=1S/C30H35N3O4/c1-21(2)24-9-3-4-12-27(24)37-20-23(34)19-32-15-13-31(14-16-32)17-18-33-29(35)25-10-5-7-22-8-6-11-26(28(22)25)30(33)36/h3-12,21,23,34H,13-20H2,1-2H3
Affinity DataKi:  1.48E+3nMAssay Description:Antagonist activity at human adrenergic beta3 receptor expressed in CHOK1 cells assessed as inhibition of cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair