BDBM50320714 2-{3-[3-Fluoro-5-(4-methoxytetrahydro-4H-4-pyranyl)phenoxy]propyl}-5-(4-methanesulfonylbenzyl)-8-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride::CHEMBL1163223

SMILES COc1ccc2n(Cc3ccc(cc3)S(C)(=O)=O)c3CCN(CCCOc4cc(F)cc(c4)C4(CCOCC4)OC)Cc3c2c1

InChI Key InChIKey=FKSGBRHXQNWANA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50320714   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320714(2-{3-[3-Fluoro-5-(4-methoxytetrahydro-4H-4-pyranyl...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of 5-hydroxyeicosatetraenoic acid production by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320714(2-{3-[3-Fluoro-5-(4-methoxytetrahydro-4H-4-pyranyl...)
Affinity DataIC50:  7.66E+4nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 production by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320714(2-{3-[3-Fluoro-5-(4-methoxytetrahydro-4H-4-pyranyl...)
Affinity DataIC50:  1.09E+5nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of 12-hydroxyheptadecatrienoic acid production by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed