BDBM50322906 CHEMBL1210358::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-3-yl)methylsulfonamido)benzamide

SMILES CS(=O)(=O)N(c1cccnc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F

InChI Key InChIKey=XGQFYIAWNPUACI-URLMMPGGSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50322906   

TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322906(CHEMBL1210358 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322906(CHEMBL1210358 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322906(CHEMBL1210358 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322906(CHEMBL1210358 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322906(CHEMBL1210358 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  21nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed