BDBM50322910 CHEMBL1210354::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-2-methyl-3-(N-phenylmethylsulfonamido)benzamide

SMILES Cc1c(cccc1C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N(c1ccccc1)S(C)(=O)=O

InChI Key InChIKey=XYPSUEPECMURMW-IGYGKHONSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50322910   

TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322910(CHEMBL1210354 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  26nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322910(CHEMBL1210354 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  620nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322910(CHEMBL1210354 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed