BDBM503242 (2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]- 2-methyl-N-(2-{1-[alpha,alpha- 2H-benzyl]piperidin-4-yl}ethyl)piperazine-1-carboxamide::US11033539, Cpd. No. 21-16::US11033539, Cpd. No. 21-17

SMILES C[C@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(c(N)n1)C(F)(F)F

InChI Key InChIKey=UEUYDRJDYJUBTN-SFHVURJKSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 503242   

TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi:  55nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi:  55nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi:  55nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi:  55nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Neurocrine Biosciences

US Patent
LigandPNGBDBM503242((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent