BDBM50327390 5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-yl)-N-isopropylthiazol-2-amine::CHEMBL1258633

SMILES CC(C)Nc1ncc(s1)-c1cc(nc(n1)-c1ccccn1)-c1ccccc1Cl

InChI Key InChIKey=BEBZPLUXTCGKDB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50327390   

TargetLIM domain kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  252nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  362nMAssay Description:Inhibition of LIMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  252nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327390(5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed