BDBM50327592 5-fluoro-6-(3-(4-(6-fluoronaphthalen-1-yl)piperazin-1-yl)propoxy)isoindolin-1-one::CHEMBL1258763

SMILES Fc1ccc2c(cccc2c1)N1CCN(CCCOc2cc3C(=O)NCc3cc2F)CC1

InChI Key InChIKey=NUHXXOFRYNFFKK-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50327592   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327592(5-fluoro-6-(3-(4-(6-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to human 5HT1A receptor expressed in HeLa cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327592(5-fluoro-6-(3-(4-(6-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  1.86nMAssay Description:Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327592(5-fluoro-6-(3-(4-(6-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  9.22nMAssay Description:Displacement of [3H]-citalopram from human serotonin transporter expressed in HEK 293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327592(5-fluoro-6-(3-(4-(6-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  22.2nMAssay Description:Displacement of [3H]-citalopram from human serotonin transporter expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327592(5-fluoro-6-(3-(4-(6-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  38.5nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed