BDBM50327627 5-fluoro-6-(4-(4-(7-fluoronaphthalen-1-yl)piperazin-1-yl)butoxy)isoindolin-1-one::CHEMBL1258762

SMILES Fc1ccc2cccc(N3CCN(CCCCOc4cc5C(=O)NCc5cc4F)CC3)c2c1

InChI Key InChIKey=QNYPKNGYEMSOEU-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327627   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327627(5-fluoro-6-(4-(4-(7-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  1.77nMAssay Description:Binding affinity to human 5HT1A receptor expressed in HeLa cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327627(5-fluoro-6-(4-(4-(7-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327627(5-fluoro-6-(4-(4-(7-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327627(5-fluoro-6-(4-(4-(7-fluoronaphthalen-1-yl)piperazi...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-citalopram from human serotonin transporter expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed