BDBM50328331 1-(2-fluorophenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol::CHEMBL1258257

SMILES OC(CNC1CCN(CC1)c1ncnc2scc(-c3ccccc3)c12)COc1ccccc1F

InChI Key InChIKey=LLFZUKMTOZHVQK-UHFFFAOYSA-N

Data  3 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50328331   

TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50328331(1-(2-fluorophenoxy)-3-(1-(5-phenylthieno[2,3-d]pyr...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50328331(1-(2-fluorophenoxy)-3-(1-(5-phenylthieno[2,3-d]pyr...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50328331(1-(2-fluorophenoxy)-3-(1-(5-phenylthieno[2,3-d]pyr...)
Affinity DataKi:  433nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50328331(1-(2-fluorophenoxy)-3-(1-(5-phenylthieno[2,3-d]pyr...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human recombinant adrenergic beta1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50328331(1-(2-fluorophenoxy)-3-(1-(5-phenylthieno[2,3-d]pyr...)
Affinity DataEC50:  8.30nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
4Sc

Curated by ChEMBL
LigandPNGBDBM50328331(1-(2-fluorophenoxy)-3-(1-(5-phenylthieno[2,3-d]pyr...)
Affinity DataIC50:  220nMAssay Description:Antagonist activity at human recombinant adrenergic beta2 receptor expressed in CHO cells assessed as inhibition of isoproterenol-induced cyclic AMP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed