BDBM503306 6-amino-2-[(3S,4S)-4-amino-3- methyl-2-oxa-8-azaspiro- [4.5]decan-8-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide::US11033547, Compound 5

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(N)c(-c3cccc(Cl)c3Cl)c(n2)C(N)=O)[C@@H]1N

InChI Key InChIKey=OVNUPQDCYGPJAD-MGPLVRAMSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 503306   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503306(6-amino-2-[(3S,4S)-4-amino-3- methyl-2-oxa-8-azasp...)
Affinity DataIC50:  72nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent