BDBM50333241 CHEMBL254781::N-(4-chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)-oxalamide::N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide

SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)C(=O)Nc1ccc(Cl)cc1

InChI Key InChIKey=ZKXLQCIOURANAD-UHFFFAOYSA-N

Data  8 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50333241   

TargetEnv polyprotein(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50:  610nMAssay Description:Inhibition of HIV-1 isolate YTA48P HIV-1 gp120More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Bryn Mawr College

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50:  7.37E+4nMAssay Description:Inhibition of HIV1 YU2 gp120 binding to CD4 expressing Cf2Th-CD4/CCR5 cells assessed as inhibition of viral infection after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Bryn Mawr College

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataKd:  3.70E+3nMAssay Description:Binding affinity to HIV1 YU2 gp120 by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50:  170nMAssay Description:Binding affinity to HIV1 cYTA48P envelope glycoprotein gp120 infected in human TZM-b1 cells assessed as induction of conformational changes measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50:  270nMAssay Description:CD4 mimetic activity at gp120 in HIV-1 KP-5mvcR infected in human TZM-bl cells assessed as inhibition of viral entry by measuring reduction in RLU by...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of HIV1 KP-5mp1 gp120 interaction with CD4 human TZM-bl cells assessed as decrease in viral entry by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50333241(CHEMBL254781 | N-(4-chlorophenyl)-N'-(2,2,6,6-tetr...)
Affinity DataIC50:  170nMAssay Description:Inhibition of HIV1 KP-5mvcR gp120 interaction with CD4 in human TZM-bl cells assessed as decrease in viral entry by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed