BDBM503346 2-(2-Aminomethyl-azetidin-1-yl)-5- (2,3-dichloro-phenyl)-6-methyl- pyrimidine-4-carboxylic acid amide::US11033547, Compound 46::US11696916, Compound 46

SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC1CN

InChI Key InChIKey=KQRBBJFLHPSKTF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503346   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503346(2-(2-Aminomethyl-azetidin-1-yl)-5- (2,3-dichloro-p...)
Affinity DataIC50:  5.50E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503346(2-(2-Aminomethyl-azetidin-1-yl)-5- (2,3-dichloro-p...)
Affinity DataIC50:  5.50E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent