BDBM50335376 (S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::(S,Z)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::CHEMBL1651523

SMILES COc1cc(O)c2c(CCCCCC(=O)C=CC[C@H](C)OC2=O)c1

InChI Key InChIKey=JWTUFAOHKVRJNA-ZDUSSCGKSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50335376   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of ALK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
National University Of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human recombinant MEK1 expressed in insect cells after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EPHB4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cKIT by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  6.84E+3nMAssay Description:Inhibition of MEK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MK5 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MNK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RET by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TYK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of VEGFR2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
National University Of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant VEGFR1 expressed in Sf9 cells after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human recombinant c-kit kinase in cell free system after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
National University Of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  440nMAssay Description:Inhibition of human recombinant PDGFRalpha in cell free system after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
National University Of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of human recombinant PDGFRbeta expressed in insect cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National University Of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  850nMAssay Description:Inhibition of human recombinant FLT-3 kinase expressed in insect cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in Sf9 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
National University Of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant VEGFR3 in cell free system after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed