BDBM503363 6-amino-2-{[(1R,2S)-2- aminocyclohexyl]amino}-5-(2,3- dichlorophenyl)-pyrimidine-4- carboxamide::US11033547, Compound 65::US11696916, Compound 65

SMILES N[C@H]1CCCC[C@H]1Nc1nc(N)c(c(n1)C(N)=O)-c1cccc(Cl)c1Cl

InChI Key InChIKey=HZYYDNYGLLCFHE-WDEREUQCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503363   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503363(6-amino-2-{[(1R,2S)-2- aminocyclohexyl]amino}-5-(2...)
Affinity DataIC50:  3.70E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503363(6-amino-2-{[(1R,2S)-2- aminocyclohexyl]amino}-5-(2...)
Affinity DataIC50:  3.70E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent