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BDBM50336633 CHEMBL1672239::N-(4-(2-chlorobenzamido)-3-(trifluoromethyl)phenyl)picolinamide

SMILES: FC(F)(F)c1cc(NC(=O)c2ccccn2)ccc1NC(=O)c1ccccc1Cl

InChI Key: InChIKey=VOEOWZAMUAVMLK-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50336633   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50336633
PNG
(CHEMBL1672239 | N-(4-(2-chlorobenzamido)-3-(triflu...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2ccccn2)ccc1NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C20H13ClF3N3O2/c21-15-6-2-1-5-13(15)18(28)27-16-9-8-12(11-14(16)20(22,23)24)26-19(29)17-7-3-4-10-25-17/h1-11H,(H,26,29)(H,27,28)
PDB

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UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.36E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization


J Med Chem 54: 1106-10 (2011)


Article DOI: 10.1021/jm101271s
BindingDB Entry DOI: 10.7270/Q27P90C1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50336633
PNG
(CHEMBL1672239 | N-(4-(2-chlorobenzamido)-3-(triflu...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2ccccn2)ccc1NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C20H13ClF3N3O2/c21-15-6-2-1-5-13(15)18(28)27-16-9-8-12(11-14(16)20(22,23)24)26-19(29)17-7-3-4-10-25-17/h1-11H,(H,26,29)(H,27,28)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.09E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization


J Med Chem 54: 1106-10 (2011)


Article DOI: 10.1021/jm101271s
BindingDB Entry DOI: 10.7270/Q27P90C1
More data for this
Ligand-Target Pair