BDBM503374 2-((3aR,6aR)-4-Amino-hexahydro- cyclopenta-[c]pyrrol-2-yl)-5-(2,3- dichloro-phenyl)-6-methyl- pyrimidine-4-carboxylic acid amide::US11033547, Compound 76::US11696916, Compound 76

SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1C[C@@H]2CCC(N)[C@H]2C1

InChI Key InChIKey=RMQMWZYNKFDZCH-RJXBTYEGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503374   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503374(2-((3aR,6aR)-4-Amino-hexahydro- cyclopenta-[c]pyrr...)
Affinity DataIC50:  1.00E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503374(2-((3aR,6aR)-4-Amino-hexahydro- cyclopenta-[c]pyrr...)
Affinity DataIC50:  1.00E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent