BDBM50338360 (+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl)-2-methyl-1H-benzo[e]isoindol-3(2H)-one::CHEMBL1682905

SMILES CC(C)[C@](O)(c1cnc[nH]1)c1ccc2c3CN(C)C(=O)c3ccc2c1

InChI Key InChIKey=UCYQUZAJMGMKEU-HXUWFJFHSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50338360   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338360((+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338360((+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  22nMAssay Description:Inhibition of 17,20 lyase activity in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338360((+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  110nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338360((+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 11-beta-monooxygenase(Rattus norvegicus)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338360((+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of 11-hydroxylase activity in Sprague-Dawley rat adrenal glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338360((+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338360((+)-(R)-7-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  270nMAssay Description:Inhibition of 17,20 lyase activity in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed