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BDBM50339289 5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::CHEMBL1689662

SMILES: COc1ccc(cc1OC)-c1c([nH]n2c1nc(cc2=O)-c1cc(F)c(Cl)nc1Cl)C(F)(F)F

InChI Key: InChIKey=HNELZEYHAOKUFU-UHFFFAOYSA-N

Data: 1 EC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339289   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50339289
PNG
(5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-(3,4-dimet...)
Show SMILES COc1ccc(cc1OC)-c1c([nH]n2c1nc(cc2=O)-c1cc(F)c(Cl)nc1Cl)C(F)(F)F
Show InChI InChI=1S/C20H12Cl2F4N4O3/c1-32-12-4-3-8(5-13(12)33-2)15-16(20(24,25)26)29-30-14(31)7-11(27-19(15)30)9-6-10(23)18(22)28-17(9)21/h3-7,29H,1-2H3
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Similars

Article
PubMed
n/an/an/an/a 230n/an/an/an/a



Hebei Medical University

Curated by ChEMBL


Assay Description
Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay


Eur J Med Chem 46: 934-43 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.010
BindingDB Entry DOI: 10.7270/Q2TM7BDF
More data for this
Ligand-Target Pair