BDBM503398 (5P)-2-[(3aS,7aR)-3a- (aminomethyl)-octahydro-1H- isoindol-2-yl]-6-amino-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide::US11033547, Compound 101::US11033547, Compound 103::US11696916, Compound 103

SMILES NC[C@@]12CN(C[C@@H]1CCCC2)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=IKMGLAPRJVWUEO-YBTHPKLGSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 503398   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503398((5P)-2-[(3aS,7aR)-3a- (aminomethyl)-octahydro-1H- ...)
Affinity DataIC50:  75nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503398((5P)-2-[(3aS,7aR)-3a- (aminomethyl)-octahydro-1H- ...)
Affinity DataIC50:  5.60E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503398((5P)-2-[(3aS,7aR)-3a- (aminomethyl)-octahydro-1H- ...)
Affinity DataIC50:  75nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503398((5P)-2-[(3aS,7aR)-3a- (aminomethyl)-octahydro-1H- ...)
Affinity DataIC50:  5.60E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent