BDBM50340121 CHEMBL1760035::N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC

InChI Key InChIKey=FHDPQTHZTKXVCW-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50340121   

TargetInsulin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  3nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  19nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  746nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  853nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  94nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  711nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed