BDBM50340446 4-(4-(3-(1H-pyrazol-4-yl)pyrrolidine-1-carbonyl)-3,4-dihydroquinoxalin-1(2H)-yl)-N-cyclopropylbenzamide::CHEMBL1761867

SMILES O=C(NC1CC1)c1ccc(cc1)N1CCN(C(=O)N2CCC(C2)c2cn[nH]c2)c2ccccc12

InChI Key InChIKey=OSDMMAOYAANGHP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340446   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM50340446(4-(4-(3-(1H-pyrazol-4-yl)pyrrolidine-1-carbonyl)-3...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant 11beta-HSD1 assessed as conversion of radiolabelled-cortisone to cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM50340446(4-(4-(3-(1H-pyrazol-4-yl)pyrrolidine-1-carbonyl)-3...)
Affinity DataIC50:  90nMAssay Description:Inhibition of mouse recombinant 11beta-HSD1 assessed as conversion of radiolabelled-cortisone to cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed