BDBM503410 (5P)-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl]-5-(2,3- dichlorophenyl)-6- methylpyrimidine-4-carboxamide::US11033547, Compound 113::US11033547, Compound 114::US11696916, Compound 114

SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CCC[C@H]2N)CC1

InChI Key InChIKey=ZULOETSIOFVBBP-OAHLLOKOSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 503410   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503410((5P)-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl]-5...)
Affinity DataIC50:  660nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503410((5P)-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl]-5...)
Affinity DataIC50:  45nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503410((5P)-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl]-5...)
Affinity DataIC50:  660nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503410((5P)-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl]-5...)
Affinity DataIC50:  45nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent