BDBM50341433 2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-6-ol::2-[(trifluoromethyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-6-ol::CHEMBL1615276

SMILES Oc1ccc2CN(CCc2c1)S(=O)(=O)C(F)(F)F

InChI Key InChIKey=HADUTEDIBIZUBV-UHFFFAOYSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341433   

TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  1.87E+3nMAssay Description:Transcriptional activation of human ERalpha receptor transfected in human U2OS cells assessed as increase of luciferase activity by estrogen response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  310nMAssay Description:Transcriptional activation of human ERbeta receptor transfected in human U2OS cells assessed as increase of luciferase activity by estrogen response ...More data for this Ligand-Target Pair