BDBM50343197 CHEMBL1773599::N-(6-(5-(4-Methoxyphenylsulfonamido)pyridin-3-yl)benzo-[d]thiazol-2-yl)acetamide

SMILES COc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(NC(C)=O)sc2c1

InChI Key InChIKey=OOTIQBRFCRKTAU-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343197   

LigandPNGBDBM50343197(CHEMBL1773599 | N-(6-(5-(4-Methoxyphenylsulfonamid...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343197(CHEMBL1773599 | N-(6-(5-(4-Methoxyphenylsulfonamid...)
Affinity DataIC50:  11nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343197(CHEMBL1773599 | N-(6-(5-(4-Methoxyphenylsulfonamid...)
Affinity DataIC50:  103nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed