BDBM50343200 CHEMBL1615189::N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide::N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide

SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1

InChI Key InChIKey=YGBMCLDVRUGXOV-UHFFFAOYSA-N

Data  7 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50343200   

LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PI3Kalpha using PI(4,5)P2 as substrate after 20 mins by alphascreen assay in presence of 20 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PI3Kdelta expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataKi:  2nMAssay Description:Inhibition of human PI3Kbeta expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of human PI3Kgamma expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataKi:  31nMAssay Description:Inhibition of human VPS34 after 30 mins by fluorescence-based immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataIC50:  2nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataIC50:  3nMAssay Description:Inhibition of DNA-PK after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant N-terminal GST-tagged mTOR-mediated 4E-BP1 phosphorylation after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of PI3K-mediated Akt phosphorylation at Ser 473 in human U87MG cells after 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50343200(CHEMBL1615189 | N-(6-(6-Chloro-5-(4-fluorophenylsu...)
Affinity DataIC50:  120nMAssay Description:Inhibition of SMO in mouse NIH/3T3 cells assessed as inhibition of SAG-induced hedgehog-mediated luminescence signaling by GRE-luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed