BDBM50343559 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE::1-(2-hydroxyethyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1738758

SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1

InChI Key InChIKey=QHLVBNKYJGBCQJ-UHFFFAOYSA-N

Data  60 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 60 hits for monomerid = 50343559   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50:  3nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ZAP70 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK1/CYCB assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDC7/DBF4 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK5/P25 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2/CYCA assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aur-B assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK4/CYCD1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IR assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2/CYCE assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50:  510nMAssay Description:Inhibition of FLT3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50:  744nMAssay Description:Inhibition of MELK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ABL assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ACK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aur-A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BRK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BUB1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EEF2K assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EphA2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3-beta assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Haspin assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity immunoglobulin gamma Fc receptor I(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGFR1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KIT assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LYN assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MET assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MNK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MPS1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MST4 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NEK6 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase NIM1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NIM1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P38alpha assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK4 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PERK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PIM1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PIM2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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