BDBM50346601 NSC-114945::OLEANOLIC_ACID::Oleanolic acid::Oleanolic acid (OA)(Compound 1)::US11660306, Example Oleanolic acid
SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
InChI Key InChIKey=MIJYXULNPSFWEK-GTOFXWBISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 130 hits for monomerid = 50346601
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 72nMAssay Description:Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-li...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-405](Homo sapiens (Human))
Cold Spring Harbor Laboratory
US Patent
Cold Spring Harbor Laboratory
US Patent
Affinity DataKi: 2.00E+3nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-321](Homo sapiens (Human))
Cold Spring Harbor Laboratory
US Patent
Cold Spring Harbor Laboratory
US Patent
Affinity DataKi: 4.00E+3nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Mixed-type inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by double-reciprocal plot methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMpH: 7.2 T: 2°CAssay Description:Rabbit muscle glycogen phosphorylase a (RMGPa) activity was measured by the release of phosphate from glucose-1-phosphate at 655 nm. Each compound wa...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 4.23E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMpH: 6.5Assay Description:Briefly, the tested compounds were solubilized in DMSO and serially diluted into concentrations for the inhibitory test. The assays were carried out ...More data for this Ligand-Target Pair
TargetEnv polyprotein(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells aft...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of TCPTP (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibition of TCPTP (unknown origin) assessed as pNPP hydrolysis after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) assessed as pNPP hydrolysis after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PTP1B using pNPP as substrate assessed as rate of hydrolysis incubated for 10 mins prior to substrate addition measur...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.12E+4nMAssay Description:Inhibition of human LMW-PTP IF1 using p-nitrophenylphosphate as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition of human LMW-PTP IF2 using p-nitrophenylphosphate as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of PTP1B (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate and measured 30 mins post substra...More data for this Ligand-Target Pair
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibition of TCPTP (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human PTP1B using pNPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by microplate ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of recombinant human PTP1B catalytic domain assessed as hydrolysis of pNPP after 2 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: >1.20E+5nMAssay Description:Inhibition of human SHP1 as hydrolysis of pNPP after 2 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: >1.20E+5nMAssay Description:Inhibition of human SHP2 as hydrolysis of pNPP after 2 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+5nMAssay Description:Inhibition of human TCPTP as hydrolysis of pNPP after 2 minsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: >1.20E+5nMAssay Description:Inhibition of human LAR as hydrolysis of pNPP after 2 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibition of human TCPTP using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of human SHP1 using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of human SHP2 using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of human LAR using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader bas...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of GST-tagged human recombinant PTP1B assessed as dephosphorylation of para-nitrophenyl phosphate after 10 mins by spectrophotometric anal...More data for this Ligand-Target Pair
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase a assessed as release of phosphate from glucose-1-phosphate after 25 mins using malachite green st...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of inducible nitric oxide synthase in activated macrophagesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of phospholipase A2More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human AKR1B10 overexpressed in human HeLa cells assessed as inhibition of [1-14C]farnesol reduction pretreated f...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.24E+5nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as p...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of rabbit muscle GPaMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 2 mins by colorimetric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair