BDBM50346918 CHEMBL1738710

SMILES Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO

InChI Key InChIKey=XIPYKUQAZQIESI-UHFFFAOYSA-N

Data  1 KI  33 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50346918   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataKi:  193nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROCK IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50:  17nMAssay Description:Inhibition of p38alpha kinase in human monocytesMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AURKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TBK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MKK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MKK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MYT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50:  249nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50:  12nMAssay Description:Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed