BDBM50347495 CHEMBL1801578::hsp90_39

SMILES Oc1cc(O)c(cc1Cl)-n1c2ccc(CNS(=O)(=O)c3cccc4ccccc34)cc2[nH]c1=O

InChI Key InChIKey=VUQDPFXQYOUHGL-UHFFFAOYSA-N

Data  3 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50347495   

TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50347495(CHEMBL1801578 | hsp90_39)
Affinity DataIC50:  30.4nMAssay Description:FRET Assay 1More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347495(CHEMBL1801578 | hsp90_39)
Affinity DataIC50:  550nMAssay Description:Inhibition of Hsp90alpha ATPase activity by malachite green ATP-ase assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347495(CHEMBL1801578 | hsp90_39)
Affinity DataIC50:  30nMAssay Description:Binding affinity to Hsp90alpha N-terminal ATPase domain by TR-FRET assay based competitive binding assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347495(CHEMBL1801578 | hsp90_39)
Affinity DataEC50:  60nMAssay Description:Inhibition of Hsp90alpha in human SKBR3 cells assessed as up-regulation of HSP70 protein by Western blot analysisMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347495(CHEMBL1801578 | hsp90_39)
Affinity DataEC50:  190nMAssay Description:Inhibition of Hsp90alpha in human H1299 cells assessed as HIF-1alpha degradation by luciferase reporter assayMore data for this Ligand-Target Pair