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BDBM50347606 CHEMBL1802986

SMILES: FC(F)(F)c1ccc2c(c1)[nH]c1cnccc21

InChI Key: InChIKey=UEQGBTJIWXDXDG-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50347606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens)
BDBM50347606
PNG
(CHEMBL1802986)
Show SMILES FC(F)(F)c1ccc2c(c1)[nH]c1cnccc21
Show InChI InChI=1S/C12H7F3N2/c13-12(14,15)7-1-2-8-9-3-4-16-6-11(9)17-10(8)5-7/h1-6,17H
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of C-terminally His6-tagged microtubule-activated KSP motor domain ATPase activity after 15 mins by luciferase-derived luminescence assay


J Med Chem 54: 4839-46 (2011)


Article DOI: 10.1021/jm200448n
BindingDB Entry DOI: 10.7270/Q20V8D5G
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50347606
PNG
(CHEMBL1802986)
Show SMILES FC(F)(F)c1ccc2c(c1)[nH]c1cnccc21
Show InChI InChI=1S/C12H7F3N2/c13-12(14,15)7-1-2-8-9-3-4-16-6-11(9)17-10(8)5-7/h1-6,17H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged KSP ATPase motor domain (unknown origin) expressed in bacteria incubated for 30 mins prior to ATP addition measur...


Bioorg Med Chem 22: 3171-9 (2014)


Article DOI: 10.1016/j.bmc.2014.04.008
BindingDB Entry DOI: 10.7270/Q2ST7RD5
More data for this
Ligand-Target Pair