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BDBM50348014 CHEMBL1800411

SMILES: CC1(C)CC(CCO1)(NC(=S)Nc1cccc(F)c1)c1ccccc1

InChI Key: InChIKey=WCQOWJRKUQCNQM-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50348014   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoprenylcysteine carboxyl methyltransferase


(Homo sapiens (Human))
BDBM50348014
PNG
(CHEMBL1800411)
Show SMILES CC1(C)CC(CCO1)(NC(=S)Nc1cccc(F)c1)c1ccccc1
Show InChI InChI=1S/C20H23FN2OS/c1-19(2)14-20(11-12-24-19,15-7-4-3-5-8-15)23-18(25)22-17-10-6-9-16(21)13-17/h3-10,13H,11-12,14H2,1-2H3,(H2,22,23,25)
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PC sid
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Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Myrexis Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...


J Med Chem 54: 5031-47 (2011)


Article DOI: 10.1021/jm200249a
BindingDB Entry DOI: 10.7270/Q2XW4K49
More data for this
Ligand-Target Pair