BDBM50348710 CHEMBL1801506

SMILES CC(C)Cc1nc2nccnc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12

InChI Key InChIKey=VRWVDFOGASQGSR-UHFFFAOYSA-N

Data  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50348710   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50:  2.90E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50:  440nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50:  88nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50:  300nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as inhibition ionomycin induced nitric oxide production incubated for 24 hrs measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50:  3.90E+4nMAssay Description:Inhibition of human eNOS expressed in HEK293 cells assessed as inhibition A23187 induced nitric oxide production incubated for 24 hrs measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed