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BDBM50348955 CHEMBL1808090

SMILES: CCOC(=O)C=Cc1c(Oc2cccc(OC)c2)nc[nH]c1=O

InChI Key: InChIKey=KHGNJLNSBJVYFR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50348955   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50348955
PNG
(CHEMBL1808090)
Show SMILES CCOC(=O)C=Cc1c(Oc2cccc(OC)c2)nc[nH]c1=O
Show InChI InChI=1S/C16H16N2O5/c1-3-22-14(19)8-7-13-15(20)17-10-18-16(13)23-12-6-4-5-11(9-12)21-2/h4-10H,3H2,1-2H3,(H,17,18,20)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged NPM-ALK using biotinylated-poly(GT) peptide as substrate after 60 mins


Bioorg Med Chem Lett 21: 4592-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.103
BindingDB Entry DOI: 10.7270/Q2N87B4V
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50348955
PNG
(CHEMBL1808090)
Show SMILES CCOC(=O)C=Cc1c(Oc2cccc(OC)c2)nc[nH]c1=O
Show InChI InChI=1S/C16H16N2O5/c1-3-22-14(19)8-7-13-15(20)17-10-18-16(13)23-12-6-4-5-11(9-12)21-2/h4-10H,3H2,1-2H3,(H,17,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of recombinant MET using biotinylated-poly(GT) peptide as substrate after 60 mins


Bioorg Med Chem Lett 21: 4592-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.103
BindingDB Entry DOI: 10.7270/Q2N87B4V
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50348955
PNG
(CHEMBL1808090)
Show SMILES CCOC(=O)C=Cc1c(Oc2cccc(OC)c2)nc[nH]c1=O
Show InChI InChI=1S/C16H16N2O5/c1-3-22-14(19)8-7-13-15(20)17-10-18-16(13)23-12-6-4-5-11(9-12)21-2/h4-10H,3H2,1-2H3,(H,17,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of recombinant IRK using biotinylated-poly(GT) peptide as substrate after 60 mins


Bioorg Med Chem Lett 21: 4592-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.103
BindingDB Entry DOI: 10.7270/Q2N87B4V
More data for this
Ligand-Target Pair