BDBM50349866 CHEMBL160296::CHEMBL1813590::UNC10108016::US9156822, 39
SMILES COc1ccccc1N1CCN(CCCCOc2ccc3CCC(=O)Nc3c2)CC1
InChI Key InChIKey=HVSUPPZVIPTMEM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50349866
Affinity DataKi: 0.220nMAssay Description:Displacement of [125I]ABN from human recombinant D2L receptor expressed in HEK cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in CHO cells after 1.5 hrs by microbeta counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.320nMpH: 7.4Assay Description:Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well...More data for this Ligand-Target Pair
Affinity DataKi: 13.1nMAssay Description:Displacement of [125I]ABN from human recombinant D3 receptor expressed in HEK cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
Affinity DataKi: 212nMAssay Description:Displacement of [125I]ABN from human recombinant D4 receptor expressed in HEK cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Washington University
Curated by ChEMBL
Washington University
Curated by ChEMBL
Affinity DataKi: 1.18E+3nMAssay Description:Displacement of [3H](+)-pentazocine from guinea pig brain sigma-1 receptor after 90 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Partial agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Partial agonist activity at human D2L receptor expressed in HEK293T cells coexpressing Gi subunit assessed as inhibition of isoproterenol-stimulated ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMpH: 7.4Assay Description:Recruitment of β-arrestin to agonist-stimulated D2 receptors was performed using a previously described Tango-type assay (Barnea et al., Proc. N...More data for this Ligand-Target Pair