BDBM50353046 CHEMBL1822525
SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)N1CCN(C[C@H](C)O)CC1
InChI Key InChIKey=PYEVUJXYLLDVLP-FQEVSTJZSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50353046
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant ALK assessed as phosphorylated product using PLC-gamma/GST substrate by modified ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human GST-tagged ALK expressed in SF21 insect cells using PLCgamma/GST as substrate after 15 mins by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cephalon
Curated by ChEMBL
Cephalon
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human ERG channel by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 379nMAssay Description:Inhibition of human recombinant JAK2 using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair