BDBM50353589 CHEMBL1828979

SMILES Cc1noc(C)c1-c1ccccc1

InChI Key InChIKey=BHAXDAUULXCVEK-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50353589   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Dana-Farber Institute

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibition of BRD4 (unknown origin) by biotinylated-JQ1 based AlphaScreen BRD binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataIC50:  3.43E+4nMAssay Description:Displacement of H4Ac4 peptide from first bromodomain of human BRD2 by peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataIC50: >2.00E+5nMAssay Description:Displacement of H3K56Ac from human CREBBP by peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Dana-Farber Institute

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) measured by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Dana-Farber Institute

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataIC50:  800nMAssay Description:Displacement of FITC-labeled (+)-JQ1 from bromodomain BRD4(1) (unknown origin) expressed in Escherichia coli BL21(DE3) after 4 hrs by fluorescence an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Dana-Farber Institute

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataKd:  50nMAssay Description:Binding affinity to human His-tagged bromodomain BRD4(1) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Dana-Farber Institute

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataIC50:  1.58E+5nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) measured by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Dana-Farber Institute

Curated by ChEMBL
LigandPNGBDBM50353589(CHEMBL1828979)
Affinity DataIC50:  8.42E+4nMAssay Description:Displacement of H4Ac4 peptide from first bromodomain of human BRD4 by peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed