BindingDB logo
myBDB logout

BDBM50353877 CHEMBL1830351::US9006187, 16

SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ccc(OC3CCOC3)cc2)c(Cl)s1

InChI Key: InChIKey=SEHAOHGADQPFJS-TVXCUULYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50353877   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353877
PNG
(CHEMBL1830351 | US9006187, 16)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ccc(OC3CCOC3)cc2)c(Cl)s1
Show InChI InChI=1S/C21H25ClO7S/c22-21-12(7-11-1-3-13(4-2-11)28-14-5-6-27-10-14)8-16(30-21)20-19(26)18(25)17(24)15(9-23)29-20/h1-4,8,14-15,17-20,23-26H,5-7,9-10H2/t14?,15-,17-,18+,19-,20+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 162n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50353877
PNG
(CHEMBL1830351 | US9006187, 16)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ccc(OC3CCOC3)cc2)c(Cl)s1
Show InChI InChI=1S/C21H25ClO7S/c22-21-12(7-11-1-3-13(4-2-11)28-14-5-6-27-10-14)8-16(30-21)20-19(26)18(25)17(24)15(9-23)29-20/h1-4,8,14-15,17-20,23-26H,5-7,9-10H2/t14?,15-,17-,18+,19-,20+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 162n/an/an/an/a7.437



Green Cross Corporation

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9006187 (2015)


BindingDB Entry DOI: 10.7270/Q29K490H
More data for this
Ligand-Target Pair