BDBM50365463 CHEMBL1232461
SMILES CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12
InChI Key InChIKey=AAAQFGUYHFJNHI-SFHVURJKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 96 hits for monomerid = 50365463
Affinity DataKi: 23nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD3 BD2 (306 to 417 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Displacement of Alexa647-labeled JQ1 derivative from wild type BRD4 bromodomain 2 (44 to 460 residues) N433A mutant (unknown origin) incubated for 1 ...More data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE...More data for this Ligand-Target Pair
Affinity DataKi: 49nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD2 BD2 (349 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Displacement of Alexa647-labeled JQ1 derivative from wild type BRD4 bromodomain 1 (44 to 460 residues) N140A mutant (unknown origin) incubated for 1 ...More data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Displacement of Alexa647-labeled JQ1 derivative from wild type BRD4 tandem domain (44 to 460 residues) (unknown origin) incubated for 1 hr by fluores...More data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD3 BD1 (24 to 144 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
Affinity DataKi: 57nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD2 BD1 (72 to 205 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
Affinity DataKi: 66nMAssay Description:Binding affinity to human recombinant BRD4 BD2 (333 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 69nMAssay Description:Binding affinity to human recombinant BRD3 BD1 (24 to 144 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 74nMAssay Description:Binding affinity to human recombinant BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 74nMAssay Description:Binding affinity to human recombinant BRD4 BD1 (44 to 168 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 94nMAssay Description:Binding affinity to human recombinant BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 94nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain2 after 60 mins by HTR...More data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Binding affinity to human recombinant BRD2 BD1 (72 to 205 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 163nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after...More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after 60 mins by HTR...More data for this Ligand-Target Pair
Affinity DataIC50: 32.5nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd2 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 42.4nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd3 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 36.1nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd4 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 790nMAssay Description:Inhibition of BRD2 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of BRD3 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of BRD4 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
Affinity DataIC50: 156nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
Affinity DataKd: 159nMAssay Description:Binding affinity to biotinylated BRD2 BD1 (72 to 205 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferometr...More data for this Ligand-Target Pair
Affinity DataKd: 45nMAssay Description:Binding affinity to biotinylated BRD2 BD2 (349 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferomet...More data for this Ligand-Target Pair
Affinity DataKd: 61nMAssay Description:Binding affinity to biotinylated BRD3 BD1 (24 to 144 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferometr...More data for this Ligand-Target Pair
Affinity DataKd: 41nMAssay Description:Binding affinity to biotinylated BRD3 BD2 (306 to 417 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferomet...More data for this Ligand-Target Pair
Affinity DataKd: 99nMAssay Description:Binding affinity to biotinylated BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferometr...More data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding affinity to biotinylated BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferomet...More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to biotinylated CREBBP (1043 to 1159 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferomet...More data for this Ligand-Target Pair
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to biotinylated ATAD2A (981 to 1108 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferometr...More data for this Ligand-Target Pair
Affinity DataKd: 65nMAssay Description:Binding affinity to N-terminal His6-tagged-BRD4 bromodomain 2 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by isothermal ...More data for this Ligand-Target Pair
Affinity DataKd: 95nMAssay Description:Binding affinity to N-terminal His6-tagged-BRD4 bromodomain 1 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by isothermal ...More data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding affinity to full length N-terminal His6-tagged-BRD2 bromodomain 2 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by...More data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding affinity to full length N-terminal His6-tagged-BRD2 bromodomain 1 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human His-tagged BRD4 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human His-tagged BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Displacement of biotinylated tetra-acetylated histone H4 from human his-tagged BRD4 bromodomain1 by FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 61.3nMAssay Description:Binding affinity to BRD2-BD1,2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 50.5nMAssay Description:Binding affinity to BRD3-BD1,2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 55.2nMAssay Description:Binding affinity to BRD4-BD1,2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 32.5nMAssay Description:Displacement of acetylated histone peptide from BRD2-BD1,2 by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 42.4nMAssay Description:Displacement of acetylated histone peptide from BRD3-BD1,2 by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36.1nMAssay Description:Displacement of acetylated histone peptide from BRD4-BD1,2 by FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 49nMAssay Description:Binding affinity to His6-tagged BRD4 expressed in Escherichia coli by isothermal colorimetric analysisMore data for this Ligand-Target Pair