BDBM50366613 DEXTROMETHORPHAN
SMILES COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1
InChI Key InChIKey=MKXZASYAUGDDCJ-NJAFHUGGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50366613
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The State University of New Jersey
Curated by ChEMBL
The State University of New Jersey
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 1 hr in presence of 250 uM phenytoin liquid sc...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The State University of New Jersey
Curated by ChEMBL
The State University of New Jersey
Curated by ChEMBL
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 348nMAssay Description:Inhibition of [3H](+)-pentazocine binding to Sigma receptor type 1More data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Affinity DataKi: 4.80E+3nMAssay Description:Displacement of [3H]BTX from sodium channel of rat cerebral cortex synaptosomesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Albany Molecular Research, Inc.
Curated by ChEMBL
Albany Molecular Research, Inc.
Curated by ChEMBL
Affinity DataKi: 5.07E+3nMAssay Description:Binding affinity was measured as selectivity for sigma-1 site over muscarinic (M1) receptor in ratMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]saxitoxin binding to rat brain sodium channelMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of [3H]batrachotoxin binding to rat brain sodium channelMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The State University of New Jersey
Curated by ChEMBL
The State University of New Jersey
Curated by ChEMBL
Affinity DataIC50: 15.2nMAssay Description:Displacement of [3H]pentazocine from sigma1 receptor in guinea pig membrane in presence of phenytoinMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The State University of New Jersey
Curated by ChEMBL
The State University of New Jersey
Curated by ChEMBL
Affinity DataIC50: 232nMAssay Description:Displacement of [3H]pentazocine from sigma1 receptor in guinea pig membraneMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Medical University of Lublin
Curated by ChEMBL
Medical University of Lublin
Curated by ChEMBL
Affinity DataIC50: 1.11E+4nMAssay Description:Non-competitive inhibition of rat alpha3beta4 nAChR expressed in KX cells assessed as reduction in current by whole-cell patch clamp assayMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.64E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 15 to 40 mins in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair