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BDBM50374284 CHEMBL256270

SMILES: COC(=O)c1ccc2oc(nc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1

InChI Key: InChIKey=ZEYKCKHIIXIHTH-QHCPKHFHSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50374284   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (Human))
BDBM50374284
PNG
(CHEMBL256270)
Show SMILES COC(=O)c1ccc2oc(nc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1
Show InChI InChI=1S/C30H25N5O6/c1-40-30(39)20-12-13-24-22(15-20)34-28(41-24)26(37)23(14-18-8-4-2-5-9-18)33-25(36)17-35-27(19-10-6-3-7-11-19)32-16-21(31)29(35)38/h2-13,15-16,23H,14,17,31H2,1H3,(H,33,36)/t23-/m0/s1
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PC cid
PC sid
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Similars

Article
PubMed
5.60n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human chymase


Bioorg Med Chem 16: 1562-95 (2008)


Article DOI: 10.1016/j.bmc.2007.11.015
BindingDB Entry DOI: 10.7270/Q21J9BNH
More data for this
Ligand-Target Pair