BDBM50374608 CHEMBL410295

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1

InChI Key InChIKey=BHJJWVDKNXABFS-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50374608   

TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of JNK3 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  540nMAssay Description:Inhibition of b-Raf by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MSK1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human T-cell receptor zeta chain phosphorylation in Jurkat cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  7nMAssay Description:Inhibition of Lck by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  120nMAssay Description:Inhibition of Src by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  21nMAssay Description:Inhibition of Lyn by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of ZAP-70 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Tyk2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  150nMAssay Description:Inhibition of JAK3 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  410nMAssay Description:Inhibition of Btk by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  560nMAssay Description:Inhibition of c-Kit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38-alpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  200nMAssay Description:Inhibition of Syk by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Itk by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50:  750nMAssay Description:Inhibition of Tie-2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed